A8717
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 | Immunoblotting Rat brain cytosolic S1 fraction was separated on SDS-PAGE and probed with IgG Fraction AB APP, C-Terminal (RB) (BM# 3088) (Cat. No. A8717). The antibody was developed with Alk’ Phos’ APA Rabbit IgG (Cat. No. A9919) and NBT/BCIP substrate. Antibody dilution 1/8,000. |
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A8717
Sigma
Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
| Synonym: | Anti-APP |
| MDL number: | MFCD02095828 |
Description
| Immunogen | synthetic peptide corresponding to the C-terminal of human APP695 (amino acids 676-695) conjugated to KLH. |
| Specificity | The immunogen sequence is identical to rat and mouse APP695 and in the APP isoforms APP751 and APP770. The antibody recognizes APP695, APP751 and APP770. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
Properties
| antibody form | IgG fraction of antiserum |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| mol wt | antigen mol wt 95-100 kDa |
| species reactivity | rat, mouse, human |
| application(s) | immunoblotting: 1:4,000 using rat brain extract |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000 using formic acid-treated sections of human Alzheimer's disease (AD) brain | |
| microarray: suitable | |
| Gene Information | human ... APP(351) |
| rat ... App(54226) | |
| mouse ... App(11820) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
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References
| reference | Greco, C., et al., Knockdown of ACAT-1 Reduces Amyloidogenic Processing of APP FEBS Lett. 8, 522-531, (2008) |
| Cameron, A., et al., Depletion of GGA3 stabilizes BACE and enhances β-secretase activity Neuron 8, 389-401, (2008) |
